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Historia SFC/ENMI
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Historia SFC/ENMI
Laboratorio Fatiga
25 % SFC



Utilice nuestro Auto-Test Síndrome de Fatiga Crónica (SFC) para valorar sus posibilidades de padecer el Síndrome de Fatiga Crónica (SFC).

Acceda al Listado de Síntomas del CDC en su versión de 2005



Programa de actividad física en Síndrome de Fatiga Crónica (SFC) (pdf 70 Kb)

Ayúdenos !. Pulse en la tarjeta FibroCARD para apoyar de forma efectiva la investigación en FM y SFC (enlace externo a "la Caixa")


Infórmese sobre el "Registro de pacientes con Fibromialgia y/o Síndrome de Fatiga Crónica (SFC)".

 "Escuchar al paciente". Las diferencias entre FM y Síndrome de Fatiga Crónica (SFC) (pdf 27 Kb.)

 "El mito de la depresión en la fibromialgia" (pdf 12 Kb.)

Enlace con la Revista Biorritmes sobre FM y Síndrome de Fatiga Crónica (SFC)

La revista "Biorritmes" es de divulgación general sobre FM y SFC. Sus artículos no reflejan necesariamente nivel de evidencia científica.



Aunque actualmente el Síndrome de Fatiga Crónica Postviral y la Encefalomielitis Miálgica Benigna comparte epígrafe en el Código Internacional de Enfermedades, en el inicio de su desarrollo como entidades patológicas existían claras diferencias, como por ejemplo en el aspecto epidémico y en el importante impacto cognitivo.

Conocer un poco de historia al respecto, puede ayudarnos a establecer algunos matices diferenciales.

En 1956 aparece en "The Lancet", el primer artículo proponiendo una denominación para la enfermedad y posteriormente, en 1958 y 1959 se desarrolla el conceto y la definición de Encefalolimielitis Miálgica Benigna en sendos trabajos históricos, que puede reproducir pinchando en los siguientes enlaces:

Algunas referencias epidémicas

Acheson ED. The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland Disease, and epidemic neuromyasthenia. American Journal of Medicine 1959; 26: 569-95.

Ball AP. Disease due to echovirus type 19 in Birmingham, England, 1975. Postgraduate Medical Journal 1978; 54: 737-40.

Abstract: In the summer of 1975 an extensive epidemic of disease due to echovirus type 19 occurred in the West Midlands. The features of this outbreak, and their relationship to the syndrome referred to as 'epidemic neuromyasthenia', are discussed. The two diseases are considered to be separate entities.

Behan PO. Epidemic myalgic encephalomyelitis. Practitioner 1980; 224: 805-7.

Compston N. An outbreak of encephalomyelitis in the Royal Free Hospital Group, London, in 1955. Postgraduate Medical Journal 1978; 54: 722-24.

Corridan JP. 'Epidemic neuromyasthenia' in Southwest Ireland. Postgraduate Medical Journal 1978; 54: 731-36.

Abstract: During the course of an obscure illness in a teenage girl it was eventually realized that the diagnosis was 'epidemic neuromyasthenia'. The illness which occurred between February and September 1976 was characterized by fatigue, pallor, headache, nuchal pain, alterations in mentation, dizziness, nausea and vomiting, paraesthesiae, weakness and heaviness of limbs, and a prolonged relapsing course. Investigation brought to light fourteen patients with similar symptoms-twelve female and two male. In view of the shortcomings of retrospective enquiries, especially those involving the assessment of notes made by other people, and the problem of trying to define a nonfatal illness with protean symptoms, many of a nonspecific nature, with few physical findings and negative laboratory studies, caution is necessary. Under these circumstances it is claimed on clinical epidemiological evidence that a diagnosis of 'epidemic neuromyasthenia' could be sustained confidently in three patients and probably in a fourth. Six patients were considered possible cases and four were rejected.

Currie DM, Shelokov A. Repetitive stimulation abnormalities in 'epidemic neuromyasthenia': identification and implications. [Abstract] Postgraduate Medical Journal 1978; 54: 746.

Daikos GK, Garzonis S, Paleologue A, Bousvaros GA. Benign myalgic encephalomyelitis: an outbreak in a nurses' school in Athens. Lancet 1959; 1: 693-6.

Dillon MJ, et al. Epidemic neuromyasthenia: outbreak among nurses at a children's hospital. British Medical Journal 1974; 1: 301-5.

Dillon MJ. 'Epidemic neuromyasthenia' at the Hospital for Sick Children, Great Ormond Street, London. Postgraduate Medical Journal 1978; 54: 725-30.

Abstract: An outbreak of an illness with features in common with 'epidemic neuromyasthenia' affected the staff of the Hospital for Sick Children in London between August 1970 and January 1971. At least 145 cases were observed and the majority of these were nurses. Symptomatology was protean, clinical findings minimal and relapses frequent. Care was taken to minimize anxiety and fear in a vulnerable population, and laboratory investigations were purposefully limited in number for this reason. In general, laboratory findings, including virological investigations were negative. A high incidence of anti-complementary activity and the presence of ill defined aggregates in some acute sera on electron microscopy were interesting and possibly significant findings suggesting the presence of immune complexes. These findings, plus the ability of lymphocytes from some patients to proliferate in vitro, were thought to represent possible evidence of an infective process. Although no children were affected during the 1970 outbreak, it is interesting that seven children have recently been referred to the hospital with features compatible with 'epidemic neuromyasthenia'.

Editorial. A new clinical entity? Lancet 1956; 1: 789-90.

Editorial. Outbreak of the Royal Free. Lancet 1955; 2: 351.

Henderson DA, Shelokov A. Epidemic neuromyasthenia - clinical syndrome. New England Journal of Medicine 1959; 260: 757-64.

Hill RCJ, Cheetham RWS, Wallace HL. Epidemic myalgic encephalomyelopathy - the Durban outbreak. Lancet 1959; 1: 689-93.

Hyde B, Bergman S. Akureyri Disease (myalgic encephalomyelitis), forty years later [Letter]. Lancet 1988; 1191-2.

Macrae AD, Galpine JF. An illness resembling poliomyelitis. Lancet 1954; 2: 350-2.

Medical Staff of the Royal Free Hospital. An outbreak of encephalomyelitis, Iceland Disease, and epidemic neuromyasthenia. British Medical Journal 1957; 2: 895-904.

Parish JG. Early outbreaks of 'epidemic neuromyasthenia' Postgraduate Medical Journal 1978; 54: 711-17.

Abstract: The literature of the outbreaks of 'epidemic neuromyasthenia' (ENM) from 1934 to 1955 has been selected to show that the disease affects other people besides young adult females in hospitals and nursing homes. There have been district epidemics, in which the male: female ratio was almost even and several male outbreaks affecting soldiers in barracks. Some outbreaks appear to have been triggered off by an epidemic of poliomyelitis, and the epidemiology of outbreaks in Iceland in 1948 and 1955 suggests that the normal cytopathological effects of poliomyelitis infection have been suppressed by the new disease. In the Durban epidemic (1955) a toxic metabolite was discovered in the urine of many patients and a markedly increased urinary excretion of creatine was noted in two New York State outbreaks. The results of the transmission of an agent from patients with ENM to monkeys suggest that the neurological disorder might be in the form of mild disseminated lesions scattered throughout the nervous system from the brain to peripheral nerves and associated with perivascular round cell infiltration without significant cellular damage. ENM infection was widespread in the North of England in 1955 and associated with lymphocyte abnormalities, which have persisted in some cases for several years. This suggests a continuous organic process.

Pellow RAA, Miles JAR. Further investigations on a disease resembling poliomyelitis in Adelaide. Medical Journal of Australia 1955; 2: 480-485.

Pellow RAA. A clinical description of a disease resembling poliomylitis in Adelaide. Medical Journal of Australia 1951; 1: 944-946.

Poskanzer DC, Henderson DA, Kunkle EC, Kalter Ss, Clement WB, Bond JO. Epidemic neuromyasthenia: an outbreak in Punta Gorda Florida. New England Journal of Medicine 1957; 257: 356-64.

Ramsay AM. 'Epidemic neuromyasthenia' 1955-1978. Postgraduate Medical Journal 1978; 54: 718-21.

Abstract: A record of fifty-three patients admitted to the Infectious Diseases Department of the Royal Free Hospital between April 1955 and September 1957 suffering from 'epidemic neuromyasthenia' establishes the fact that the condition was endemic in the general population before, during and after the outbreak among the staff of the hospital. A further outbreak occurred in North Finchley between 1964 and 1967 and sporadic new cases are still being encountered. The majority of these patients show evidence of involvement of the central and sympathetic nervous systems and the reticulo-endothelial system. Abnormal muscular fatigability is the dominant clinical feature and it is suggested that mitochondrial damage may provide an explanation for this phenomenon. Enzyme tests carried out in seven cases show pathologically high levels of lactic dehydrogenase, and glutamic oxalo-acetic transaminase. A follow-up study suggests that there is one group of patients that recovers completely or nearly completely, a second that recovers but is subject to relapses and a third that shows little or no recovery, these patients remaining incapacitated.

Ramsay MA. Myalgic encephalomyelitis and postviral fatigue states: the saga of Royal Free Disease. Second Edition. Gower Publishing Co. 1988;

Richardson AT. Electromyographic studies of patients with 'epidemic neuromyasthenia' at the Royal Free Hospital. [Abstract] Postgraduate Medical Journal 1978; 54: 745.

Shelokov A, Currie DM, Nelson M. 'Epidemic neuromyasthenia', Texas 1977.[Abstract] Posgraduate Medical Journal 1978; 54: 741.

Shelokov A, Habel K, Verder E, Welsh W. Epidemic neuromyasthenia: an outbreak of poliomyelitislike illness in student nurses. New England Journal of Medicine 1957; 257: 345-55.

Sigurdsson B, Gudmundsson KR. Clinical findings six years after outbreak of Akureyri disease. Lancet 1956; 1: 766-7.

Sumner DW. Further outbreak of a disease resembling poliomyelitis. Lancet 1956; i: 764-6.

Wallis AL. An investigation into an unusual disease in epidemic and sporadic form in a general practice in Cumberland in 1955 and subsequent years. University of Edinburgh Doctoral Thesis 1957;

White DN, Burtch RB. Iceland disease: new infection simulating anterior poliomyelitis. Neurology 1954; 4: 506-16.

aPuede acceder a un documento de la organización MERGE sobre todas las incidencias epidémicas en EnMI publicadas. (pdf en inglés 137 Kb.)


aTodas las Unidades Asistenciales del IFR han superado al proceso de  inscripción y registro del Departamento de Salud (Generalitat de Catalunya) y están sometidas a controles periódicos de calidad total. Para el desarrollo de nuestra labor contamos con un equipo médico-asistencial altamente cualificado y en formación continuada.

aLa Unidad de Fibromialgia y Síndrome de Fatiga Crónica (SFC) del Institut Ferran de Reumatología cuenta con los medios diagnósticos más avanzados y con un equipo profesional experto en estas enfermedades.

a Puede acceder a un listado con otras unidades de diagnóstico del Síndrome de Fatiga Crónica (SFC) en el listado de Centros Diagnósticos del Instituto de Salud Carlos III (Ministerio de Sanidad y Consumo).  http://iier.isciii.es/er/prg/er_bus5.asp?cod_enf=540. Si tiene dificultades de conexión puede acceder al pdf de la página (21 Kb.) actualizado en fecha 11-12-2005.

aLe recomendamos que acceda a nuestro Foro de Pacientes, donde podrá contactar con otros afectados y con profesionales, obteniendo información veraz y contrastada o bien que contacte con la Fundación para la Fibromialgia y el Síndrome de Fatiga Crónica (SFC) , donde podrá ser informado de las Asociaciones de Pacientes más próximas a su domicilio que satisfacen las normas de calidad del IFR.

aSon muy recomendables los enlaces a la CFIDS Association of America y a la AACFS (American Association for Chronic Fatigue Syndrome) -enlaces externos- , aunque encontrará muchos otros de interés en nuestra página de actualización sobre Síndrome de Fatiga Crónica (SFC).

aEncontrará información detallada sobre nuestros Grupos de Ayuda Mútua (GAM), Grupos de Ejercicio Gradual (GEG) y Atención por Enfermería Especializada en nuestra página : geg.htm . Adicionalmente encontrará enlaces para poder descargar consejos para afectados y familiares.

aDescárguese la hoja informativa sobre Grupos de Soporte Psicológico Colectivo y Ejercicio Gradual en Síndrome de Fatiga Crónica (SFC) de la Fundación para la Fibromialgia y el Síndrome de Fatiga Crónica (SFC).

aUna opción de mucho interés para mejorar la movilidad de los enfermos con dolor crónico son los cursos del Método Feldenkrais, que podrá consultar en este enlace externo. (IFR no mantiene relación ni interés económico alguno en dicha propuesta).

aDesde nuestra web, puede descargar los siguientes folletos (en formato PDF) sobre el Síndrome de Fatiga Crónica (SFC):

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